10 Rat Diseases Transferred to Humans

Leptospirosis is a zoonotic disease which has the potential to cause epidemic. The bacteria which causes the disease is called Leptospira interrogans, something which can affect humans as well as other animals. As with all the diseases on this list, it is imperative for an appropriate diagnosis so effective treatment can be implemented.

The majority of cases in humans present with only mild symptoms. These include fever, headache, myalgia, general malaise and conjunctivitis. In more serious cases, about 10% of diagnoses, leptospirosis can lead to the following clinical complications:

• Weil's disease
• Meningitis
• Pulmonary hemorrhage

Treatment of leptospirosis is usually based on the administration of specific antibiotics which can kill the Leptospira bacterial infection. It can vary depending on the symptoms, progression of infection and state of health of the individual affected. This is why it is essential to go to the clinic or hospital if you see any abnormal symptoms, especially if you suspect you have received the infection from a rat.

The next zoonotic disease from rats is called the hantavirus (HV). As its name suggests, it is a viral type and belongs to the family Bunyaviridae and the genus Hantavirus. It is one of the more difficult zoonotic rat diseases to detect. The main form of infection is through direct contact or inhalation of fecal matter, urine or saliva from the species of rat and mice which can act as vectors for the pathogen^[1].

The first symptoms are relatively common to other disease and include:

• Fever
• Muscle pain
• Dizziness
• Chills
• General malaise
• Gastrointestinal disorder

As the hentavirus progresses its infection, respiratory distress and hypotension occur in most cases. These are the first signs of hantavirus cardiopulmonary syndrome (HCPS).

The current figures regarding the distribution of this pathology are alarming. Each year, 300 new cases are detected in the Americas where at least 13 endemic areas have been identified. Most of the cases were diagnosed in rural, agricultural or poorly urbanized environments, although cases in cities have been found. As with leptospirosis, hantavirus is more common in vulnerable communities, especially those with poor sanitation.

The most worrying aspect of this disease transmitted by rats is the fact there is no cure, despite the increases in diagnoses. With about 60% f henatavirus cases being fatal, early detection is key. While no cure is available, treatment of the symptoms can help the body to recover and prevent its further spread. This should ideally be carried out in an intensive care unit. Enforcing hygiene habits in the home and avoiding the accumulation of watse which may attract rats are some of the best methods of prevention.

Tularemia is caused by the bacteria Francisella tulariensis which mainly affects wild rodents and small mammals such as rats, rabbits, hares, muskrats and squirrels. It can also be found in domestic pets. Although tularemia in rabbits is the most common manifestation of the pathology, it can also affect cats, dogs, people and domestic rats.

For humans, the main cause of infection is through direct contact with tissue or blood of an infected animal. Eventually, tularemia may also be transmitted by inhalation of contaminated plant matter or soil, as well as bites from fleas, ticks mosquitos or other insects which act as vectors for the bacteria. It is possible, yet rare, for infected meat which has been poorly cooked to spread tularemia to people.

The most frequent symptoms of tularemia in people include:

• Fever
• Chills
• Excessive sweating
• Eye irritation
• Headache
• Muscle pain
• Joint stiffness
• Red spots on skin
• Respiratory difficulty
• Weightloss

Treatment of tularemia in humans is based on antibiotic treatment to both slow down the symptoms and eliminate the bacteria. Early diagnosis is, as always, incredibly important for the treatment's effectiveness.

We continue this list of rat disease transmitted to humans with bubonic plague, a bacterial zoonosis caused by the Yersinia pestis bacteria. This normally attaches itself to the bodies of small animals and parasites such as fleas. The latter is the main cause of infection in humans, biting their skin and transferring he bacteria through saliva. However, the spread of these parasites to humans is carried out by their host. Rats are one of the most common of such hosts. Inhalation or ingestion of affected animal secretions or infected organic matter can also lead to contracting the disease.

During the Middle Ages, Europe experienced the aforementioned Black Death, sometimes referred to simply as ‘The Plague’. Unfortunately, while many believe this rat borne disease is relegated to history, about 5,000 cases a year are still diagnosed across the world. The main areas of concern are the rural and semi-rural landscapes found in Asia, Africa and the United States.

The most common symptom of bubonic plague in humans is inflammation and hypersensitivity of the lymph nodes in the arm, neck and groin areas. The nodes can inflame to the size of a chicken egg and can become both painful and hot to the touch. Additionally, the following symptoms may occur in bubonic plague cases:

• Fever
• Sudden chills
• Headache
• General discomfort
• Muscle pain

In severe cases, the bacteria can reach the bloodstream. If this occurs, septicemic plague can develop. The result is severe abdominal pain, bleeding, extreme weakness, tissue necrosis and, if left untreated, sudden death. Although less frequent, the bacteria can spread to the lungs, causing respiratory problems and bloody coughing.

Plague advances rapidly in the body and, in the absence of adequate treatment, can lead to death in only a matter of days. It is essential to seek medical advice if you detect the symptoms of bubonic plague, especially if you have come in contact with rats, rat droppings or similar possible disease vectors. The treatment will be the administration of specific antibiotics, one of the reasons it is so important to seek a specialist and not treat it yourself. Treatment of the symptoms will also be carried out, such as removing dead tissue from necrotic areas.

It is essential we reinforce appropriate hygiene at home, work and anywhere else we spend our time. The accumulation of waste organic matter can attract rodents such as rats and increase the likelihood of spreading diseases such as the plague.

Toxoplasmosis is a disease which is transmitted by a protozoan called Toxoplasma gondii which can be found worldwide. Transmission can occur through many vectors, although the most common association is with cats. Most commonly, the transmission occurs through the consumption of contaminated food and water.

Felines (domestic cats, pumas, lynxes, etc.) are the main host or reservoir of toxoplasma protozoa. They are also the only animal which eliminate it through their feces. This is something we need to be extra careful with as it is our responsibility to dispose of domestic cat feces from their litterbox. The protozoa collect in cysts in their tissue.

Felines are not the only animals which can carry this cysts of toxoplasma. Sheep, cows, goats and rodents are all possible carriers. When a person consumes raw or uncooked meat from an infected animal, these cysts can activate and start their life cycle again in their new host. Toxoplasmosis can also be passed on from mother to offspring during pregnancy.

The main symptoms of toxoplasmosis in humans are:

• Lymph node swelling
• Headache
• Fever
• Muscle pain
• Sore throat
• Blurry vision

In individuals with low immunity such as pregnant women or people with chronic disease, toxoplasmosis can also cause dizziness, seizures, retinal inflammation and mental confusion. It is imperative that domestic felines receive adequate preventative medicine and have a healthy diet in the form of quality feed. If you want to know more about cats and toxoplasmosis risks, especially for pregnant women, you can take a look at out article on the subject for more information.

Another of the diseases transferred by rats to humans is salmonellosis, a well-known infectious disease caused by the bacteria genus Salmonella. The most common infections are due to Salmonella bongori and Salmonella enterica. It is currently one of the most common food borne pathologies in the world with more than one million people affected annually across the globe.

Salmonella is naturally present in the intestinal tract of birds and their eggs, as well as in some reptiles. However, the bacteria can survive in organisms of various species, including rodents like wild and domestic rats. Additionally, salmonellsis in rats can be transferred from parent to offspring, but many carriers will be asymptomatic. This means they carry the bacteria without any obvious signs of disease.

In humans, the main form of salmonellosis transmission occurs orally through the consumption of contaminated food or water, through the feces of infected animals or through the ingestion of contaminated food such as eggs, raw meat or poorly cooked meat, especially fowl. The bacteria can also enter the body through the ingestion of food which has been cooked, but has also been stored for too long or improperly. Inhalation of the bacteria can also occur.

It is estimated that a large proportion of the world has already come in contact with this bacterium, but most do not develop an infection or they have symptoms which the body can keep under control after a period of abou 2 to 7 days. However, salmonellosis will often lead to gastrointestinal problems, manifested mainly through the following symptoms:

• Nausea and vomiting
• Fever
• Chills
• Abdominal cramps
• Diarrhea
• Headache
• Dehydration
• Blood in stool

As with many on our rat borne diseases list, toxoplasmosis requires antibiotic treatment to fight the pathogenic bacteria. In some cases, analgesics are prescribed to to relieve stomach pain. If the patient is dehydrated, fluid therapy may be required to hydrate them again. Other symptoms will need to be treated, perhaps under clinical supervision depending on the vulnerability of the patient and the aggressiveness of the disease.

To prevent salmonella infections, it is important to acquire food (especially eggs and meat) that has passed all relevant hygiene controls. It is ideal to eat in certified restaurants and thoroughly wash fruit and vegetables before ingesting them. Keeping our hands clean when preparing food and avoiding cross contamination in the kitchen are also vital elements of preventing this type of disease.

If you have rats, other rodents or birds in the home, it is essential to ensure their food is not contaminated, provide them with adequate preventive medicine and maintain optimal hygiene of their living areas and accessories. We should be particularly careful when giving them human food as we might think it is OK for them, even if it isn't OK for us.

Another rat diseases transmissible to humans and coming from a bacterial origin is rat bite fever. Despite its name, it can also be transferred by the bites of other small mammals such as squirrels or weasels. In Europe and the USA, most cases are associated with the bacterium Streptobacillus moniliformis. In Asia, on the other hand, they are more related to the bacterium Spirillum minus and is known as sodoku. These pathogens make their way into the saliva, nasal secretions and urine of the rats.

With Spirillum moniliformis, the bite usually heals relatively quickly. However, after 3 to 10 days, the following symptoms may appear:

• Fever
• Chills
• Vomiting and nausea
• Diarrhea
• Headache
• Muscle pain
• Skin rash
• Joint inflammation
• Abscesses
• Meningitis
• Pneumonia
• Cardiac inflammation

In the case of sodoku caused by the S. minus bacterium, wounds should start to heal in the first week after the bite. However, between 7 and 21 days later, the following symptoms usually appear:

• Fever
• Chills
• Headache
• Muscle pain
• Ulceration
• Red patches
• Lymph node inflammation
• Skin rash
• Haverhill fever
• Vomiting
• Sore throat
• Pneumonia
• Heart infection
• Meningitis
• Hepatitis

In both cases, the treatment will consist of antibiotic administration. The specific strand of Salmonella bacteria will need to be isolated before the right treatment can be issued. The best way to avoid pet rats from contracting the disease is to maintain strict hygiene routines. We also need to ensure wild rats are kept away from our property.

Typhus is a serious infectious disease which can be caused by two types of bacteria: Rickettsia typhi and Rickettsia prowazekii. It is a disease which rats can transfer to humans that can be best avoided by engaing in proper hygiene routines. At present, two types of typhus are known:

1. Endemic typhus: transmitted by both types of typhus bacteria. When caused by R typhi, it is transmitted to humans by fleas which have previously fed on the blood of rats. In cases of R, prowazekii, lice are the intermediaries.
2. Murine typhus: this is only transmitted by the bacterium R. typhi and its main form of infection occurs through direct contact with feces or bites from infection rats. It can also be associated with out mammals such as raccoons, opossums and cats.

Symptoms of both types of typhus are similar and can present as:

• Abdominal pain
• Back pain
• High fever
• Redness
• Dry cough
• Nausea and vomiting
• Headache
• Joint pain
• Muscle pain

As a bacterial disease, typhus is also treated with the use of specific antibiotics. In more advanced cases, the doctor will need to evaluate whether the administration of oxygen and intravenous fluid therapy is necessary. Again, the best preventive measure is optimal hygiene in the home and adequate pest control.